SFB 535 - Current
Invasion and Replication Strategies of Pathogens
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Dr. med. vet. Christian Menge (sub-project A11) has held his "Habilitations" lecture "Role of T cells in equine recurrent airway obstruction" on July 3rd, 2006. The Faculty of Veterinary Medicine has accepted the presentation and promoted him to lecturer.


Big Fraction of /L. monocytogenes/ Genome Enables Intracellular Growth

Chakraborty, Hain, and Chatterjee

Listeria monocytogenes is a gram-positive, foodborne pathogen responsible for severe infections with a high overall mortality. The facultative intracellular bacterium induces its uptake into the host cell and subsequently enters the host cell cytosol by breaching the vacuolar membrane to escape into the host cytosol for multiplication. Now Torsten Hain and colleagues of the Justus-Liebig-University of Giessen, Germany, show that about one-fifth of the listerial genome is mobilized to enable adaptation of the pathogen to intracellular growth. “The global expression profiling approach allowed us to detail genes expressed during transit of the bacterium from the extracellular milieu to the vacuolar compartment and the cytosolic environment of the host cell,” says Hain. “We now know that pathogenesis of this microorganism is not only dependent on previously characterized virulence genes but is orchestrated via a large network of accessory genes, many of whose functions are unknown. The data provide a rich resource to describe and understand how this adaptation evolved and will allow us to formulate new approaches to limiting listerial infections.”

(S. S. Chatterjee, H. Hossain, S. Otten, C. Kuenne, K. Kuchmina, S. Machata, E. Domann, T. Chakraborty, and T. Hain. 2006. Intracellular gene expression profile of Listeria monocytogenes. Infect. Immun. 74:1323-1338.)

Sub-project researches of the CRC 535 have received scientific rewards:

Research award for virologist from Gießen

The department for veterinary medicine of the Justus-Liebig-University Gießen honors the virologist PD Dr. Paul Becher, TPB8, Institute for Virology of the Justus-Liebig-University Gießen, with the research award donated by the Bayer AG and the “Verein der Freunde und Förderer der Veterinärmedizin” of the Justus-Liebig-University Gießen. The award honors his outstanding work on RNA-recombination of Pestiviruses. (2004)

  Dr. Paul Becher

Carus-Medal for Prof. Katja Becker-Brandenburg
The „Deutsche Akademie für Naturforscher Loepoldina“ honors the scientist Prof. Katja Becker-Brandenburg, SP-A12, Institute für Ernährungswissenschaften at the Justus-Liebig-University for her scientific and medical research with the Carus-Medal. Specially the academy wants to honor her outstanding work on the mode of action of drugs against infectious parasites with this prestigious award.

  Prof. Dr. Katja Becker-Brandenburg

Academy award for biology 2003 for virologist from Gießen
Dr. Dieter Glebe SP-A2 from the Institut für Medizinische Virologie of the Justus-Liebig University at Gießen was honored by the academy of science at Göttingen with the academy award for biology 2003. He received the award for his development of an system for the infection of liver cells of Tupais with Hepatitis B-viruses (HBV). HBV infections are a significant worldwide health problem. More than two billion humans show signs of a passed HBV infection and more than 350 million are chronic carriers of the virus. At the moment there is no lasting effective and acceptable therapy for chronically infected patients available. The honored was able to prove that certain animal cells isolated from Tupaia-liver cells, can specifically bind and take up the virus and therefore resemble the mode of infection in the human system. Glebe developed an Tupaia-infectionsystem that can be used for the creation of new drugs and vaccines.

  Dr. Dieter Glebe

Dr. Paul Becher is honored with the award of the “German Veterinary Society“ for his successful work on isolation and characterization of Pestiviruses. (2003)

  Dr. Paul Becher

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