Sub-Projects of SFB 535
Invasion and Replication Strategies of Pathogenes
<< back  
SFB Homepage Organisation / Contact Members Announcements
Research Program Sub-Projects Publications Current
Workbench Public Seminars Internal Seminars Search
SP A15

Molecular Mimicry of Trematodes


Prof. Dr. Rudolf Geyer
Biochemisches Institut (FB 11), Justus-Liebig-Universität, Gießen



Summary

Parasitic trematodes are able to synthesize and express host-specific carbohydrate epitopes at their surface which is known as ‘molecular mimicry’. Examples are Schistosoma mansoni and Fasciola hepatica which imitate antigens of their definitive hosts like CD15 (Gal(β1-4)[Fuc(α1-3)]GlcNAcβ-, Lex) and CD77 (Gal(α>1-4)Gal(β1-4)Glc(β1-1)Cer, globotriaosylceramide, Gb3), respectively. A further example is the M2D3H-epitope (Fuc(α1-3)GalNAcβ -) which is shared by S. mansoni and its intermediate host Biomphalaria glabrata. Based on these data, the following topics are currently investigated:

Allocation of glycoconjugates with Lex-epitopes within S. mansoni cercariae and schistosomula

Structural analysis and localization of glycoconjugates from S. mansoni miracidia and B. glabrata.

Evaluation of potential immunomodulatory properties of S. mansoni glycoconjugates.

Involved scientists:

Dr. Hildegard Geyer
Dipl.-Biol. Tobias Lehr
Dipl.-Biol. Sandra Meyer
PD Dr. Roger Dennis

>> Publications
 
SFB Homepage Organisation / Contact Members Announcements
Research Program Sub-Projects Publications Current
Workbench Public Seminars Internal Seminars Search
<< back | ^ Top of Page