Parasitic trematodes are able
to synthesize and express host-specific carbohydrate epitopes at
their surface which is known as ‘molecular mimicry’.
Examples are Schistosoma mansoni and Fasciola hepatica which imitate antigens of their definitive hosts like CD15 (Gal(β1-4)[Fuc(α1-3)]GlcNAcβ-,
Lex) and CD77 (Gal(α>1-4)Gal(β1-4)Glc(β1-1)Cer,
globotriaosylceramide, Gb3), respectively. A further
example is the M2D3H-epitope (Fuc(α1-3)GalNAcβ -) which
is shared by S. mansoni and its intermediate host Biomphalaria
glabrata. Based on these data, the following topics are currently
Allocation of glycoconjugates with Lex-epitopes within
S. mansoni cercariae and schistosomula
Structural analysis and localization of glycoconjugates from
S. mansoni miracidia and B. glabrata.
Evaluation of potential immunomodulatory properties of S.
Dr. Hildegard Geyer
Dipl.-Biol. Tobias Lehr
Dipl.-Biol. Sandra Meyer
PD Dr. Roger Dennis