Publikationen des SFB 535
Invasionsmechanismen und Replikationsstrategien von Krankheitserregern
<< zurück  
SFB Homepage Organisation / Kontakt Mitglieder Ausschreibungen
Forschungsprogramm Teilprojekte Publikationen Aktuelles
Workbench öffentliche Seminare interne Seminare Suche
A2 A3 A8 A11 A12 A13 A15 A17 A18 B1 B4
B5 B8 B9 B10 B12 B13 B14 B15 Z1 Z4  

Glebe, D., Aliakbari, M., Krass, P., Knoop, E., Valerius, K.P., Gerlich, W.H. (2003)
PreS1 antigen dependent infection of Tupaia hepatocyte cultures with human hepatitis B Virus.
J Virol. 77(17):9511-21.

Schmitt S, Glebe D, Tolle TK, Lochnit G, Linder D, Geyer R, Gerlich WH.
Structure of preS2 N- and O-linked glycans in surface proteins from different genotypes of hepatitis B virus.  J Gen Virol 2004;85:2045-2053

Schmitt, S., Glebe, D., Tolle, T.K., Lochnit, G., Linder, D., Geyer, R., Gerlich W.H. (2004)
Structure of preS2 N- and O-linked glycans in surface proteins from different genotypes of hepatitis B virus. J. Gen. Virol. 85:2045-2053

Schüttler, C.G., Thomas, C., Discher, T., Friese, G., Lohmeyer, J., Schuster R., Schaefer, S., Gerlich, W.H. (2004) Variable ratio of hepatitis C virus RNA to viral core antigen in patient sera. J. Clin. Microbiol. 42 (5) p. 1977-1981

Glebe D, Urban, S, Knoop EV, Çag N, Krass P, Grün S, Bulavaite A, Sasnauskas K,  Gerlich WH. Mapping of the hepatitis B virus attachment site by infection-inhibiting preS1 lipopeptides using Tupaia hepatocytes. Gastroenterology 2005;129:234-245.

Dreesman, J.M., Baillot, A., Hamschmidt, L., Monazahian, M., Wend, U. C., Gerlich, W.H.  (2006)
Outbreak of hepatitis B in a nursing home associated with capillary blood sampling. Epidemiol. Infect. 26: 1102-1113

Schildgen, O., Sirma, H., Funk, A., Olotu, C. Wend, U.C., Hartmann, H., Helm, M., Rockstroh, J.K., Willems, W.R., Will, H., Gerlich, W.H. (2006). Variant of hepatitis B virus with Primary Resistance to Adefovir. New. Engl. J. Med. 354: 1807-1812

Gerlich, W.H. and 15 coauthors (2007) HBsAg non-reactive HBV infection in blood donors: transmission and pathogenicity. J. Med. Virol., 79, S1: S32-S36

Schaefer, S., Gerlich, W.H. (2007). Structure, replication and laboratory diagnosis of HBV and HDV.
In: Benhamou JP, Rizzetto R, Reichen R et al., eds. The Textbook of Hepatology: From Basic Science to Clinical Practice, 3rd ed., Blackwell Publishing, Oxford, p. 823-849

Baylis S.A., Heath A.B., Chudy M., Pisani G., Kloth A., Kerby S., Gerlich W.H. (2007)
An International Collaborative Study to establish the 2nd World Health Organization International Standard for Hepatitis B Virus DNA Nucleic Acid Amplification Technology (NAT)-based Assays
Vox Sang., accepted

Lu M., Yao X., Xu Y., Lorenz H., Dahmen U., Chi H., Dirsch O., Kemper T., He L., Glebe D., Gerlich W.H., Wen Y., Roggendorf M. (2008). Combination of Antiviral Drug and Immunomodulation against Hepadnaviral Infection in the Woodchuck Model. J. Virol, in press

Leistner, C., S. Grün-Bernhard, and D. Glebe. Role of glycosaminoglycans for binding and infection of hepatitis B virus. Cell. Microbiol. 2008, 10(1):122-33.

Tavakoli S, Mederacke I, Herzog-Hauff S, Glebe D, Grün S, Strand D, Urban S, Gehring A, Galle PR, Böcher WO.  Peripheral blood dendritic cells are phenotypically and functionally intact in chronic hepatitis B virus (HBV) infection. Clin Exp Immunol. 2008,  151(1): 61-70.



Kraus I, Eickmann M, Kiermayer S, Scheffczik H, Fluess M, Richt JA,
Garten W. Open reading frame III of borna disease virus encodes a nonglycosylated matrix protein. J Virol. 2001 75:12098-12104.

Kraus I, Scheffczik H, Eickmann M, Kiermayer S, Stubbs
MT, Garten W. (2002). Crystallization and preliminary
X-ray analysis of the matrix protein of Borna disease virus. Acta Crystallogr D Biol Crystallogr. 2002;58:1371-1373.

Kiermayer, S., Kraus, I., Richt, J.A., Garten, W., Eickmann, M. (2002).
Identification of the amino terminal subunit of the glycoprotein of
Borna disease virus. FEBS Letters 531: 255 - 258.

Rudolph MG, Kraus I, Dickmanns A, Eickmann M, Garten W, Ficner R.
2003. Crystal structure of the borna disease virus nucleoprotein.
Structure (Camb). 11(10): 1219-26.

Schwemmle, M, K. Carbone, M., Tomonaga, K., Garten, W. and Nowotny, N.
2004: Bornaviridae. In M. H. V. van Regenmortel and C. M. Fauquet et al.
(ed), Virus Taxonomy. 8th report of the international committee on taxonomy of viruses. Academic Press, San Diego.

Eickmann M, Kiermayer S, Kraus I, Gössl M, Richt JA, Garten W.
2005. Maturation of Borna disease virus glycoprotein. FEBS Lett.;579(21):4751-6.

Kraus I, Bogner E, Lilie H, Eickmann M, Garten W.
2005. Oligomerization and assembly of the matrix protein of Borna disease virus. FEBS Lett.:2686-92.

<< zurück | ^ Seitenanfang  

G. Lochnit, R.D. Dennis, U. Zähringer and R. Geyer
„Structural analysis of neutral glycosphingolipids from Ascaris suum adults (Nematoda: Ascaridida)“
Glycoconjugate Journal, 14, 389-399 (1997)

Stefan Gerdt, G. Lochnit, R.D. Dennis and R. Geyer
„Isolation and structural analysis of three neutral glycosphingolipids from a mixed population of Caenorhabditis elegans (Nematoda: Rhabditida)“
Glycobiology, 7, 265-275 (1997)

G. Lochnit, R.D. Dennis, A.J. Ulmer and R. Geyer
„Structural elucidation and monokine-inducing activity of two biologically active, zwitterionic glycosphingolipids derived from the porcine parasitic nematode Ascaris suum“
Journal of Biological Chemistry, 273, 466-474 (1998)

G. Lochnit, S. Nispel, R.D. Dennis and R. Geyer
„Structural analysis and immunohistochemical localization of two acidic glycosphingolipids from the porcine, parasitic nematode, Ascaris suum“
Glycobiology, 8, 891-899 (1998)

Claudia H. Friedl, G. Lochnit, R. Geyer, M. Karas and U. Bahr
"Structural elucidation of zwitterionic sugar cores from glycosphingolipids by nano-electrospray ionization-ion trap mass spectrometry"
Analytical Biochemistry, 284, 279-287 (2000)

Manfred Wuhrer, S. Rickhoff, R.D. Dennis, G. Lochnit, P.T. Soboslay, S. Baumeister and R. Geyer
„Phosphocholine-containing, zwitterionic glycosphingolipids of adult Onchocerca volvulus as highly conserved, antigenic structures of parasitic nematodes"
Biochemical Journal, 348, 417-423 (2000)

G. Lochnit, R.D. Dennis and R. Geyer
„Phosphorylcholine substituents in Nematodes: Structures, Occurrence and Biological implications“
Biological Chemistry, 381, 839-847 (2000)

G. Lochnit, R.D. Dennis, H. Müntefehr, S. Nispel and R. Geyer
„Immunohistochemical localization and differentiation of phosphocholine-containing antigens of the porcine, parasitic nematode, Ascaris suum“
Parasitology, 122, 359-370 (2001)

K. Houston*, G. Lochnit*, R. Geyer and W. Harnett
„Investigation of the nature of potential phosphorylcholine donors for filarial nematode glycoconjugates”
Molecular and Biochemical Parasitology, 123, 55-66 (2002)
* authors contributed equally

Maureen R. Deehan, H.S. Goodridge, D. Blair, G. Lochnit, R.D. Dennis, R. Geyer, M.M. Harnett and
W. Harnett
„Immunomodulatory properties of Ascaris suum glycosphingolipids – phosphorylcholine and non-phosphorylcholine – dependent effects”
Parasite Immunology, 24, 463-469 (2002)

Claudia H. Friedl, G. Lochnit, U. Zähringer, U. Bahr and R. Geyer
„Structural elucidation of zwitterionic carbohydrates from glycosphingolipids of the porcine parasitic nematode Ascaris suum”
Biochemical Journal, 369, 89-102 (2003)

G. Lochnit and R. Geyer
„Evidence of the presence of the Kennedy and Bremer-Greenberg pathways in Caenorhabditis elegans.”
Acta Biochimica Polonica, in press (2003)

TP A11


Wieler, L.H., Barbara Busse, H. Steinrück, L. Beutin, A. Weber, H. Karch, and G. Baljer (2000)
Enterohemorrhagic E. coli strains of serogroup 0118 display three distinctive clonal groups of EHEC pathogens. J. Clin. Microbiol. 38:2162-2169

Niewerth, U., A. Frey, T. Voss, C. Le Bouguenec, G. Baljer, Sylvia Franke, and M.A. Schmidt (2001)
The AIDA Autotransporter System Is Associated with F18 and Stx2e in Escherichia coli Isolates from Pigs Diagnosed with Edema Disease and Postweaning Diarrhea.
Clin. Diagn. Lab. Immunol. 8:143-149

Schoepe, Heike, C. Pache, A. Neubauer, Heidrun Potschka, T. Schlapp, L.H. Wieler, and G. Baljer (2001) Naturally Occuring Clostridium perfringens Nontoxic Alpha-Toxin Variant as a Potential Vaccine Candidate against Alpha-Toxin-Associated Diseases.
Infect. Immun. 69:7194-7196

Menge, C., Ivonne Stamm, M. Wuhrer, R. Geyer, L.H. Wieler, and G. Baljer (2001)
Globotriaosylceramide (Gb3/CD77) is synthesized and surface-expressed by bovine lymphocytes upon activation in vitro. Vet. Immunol. Immunopathol. 83(1-2):19-36

Bauerfeind, R., Stefanie Barth, R. Weiss, and, G. Baljer (2001)
Sequence polymorphism of the Salmonella plasmid virulence factor D (SpvD) in Salmonella enterica isolates of animal origin. BMTW 114:404-408

Stamm, Ivonne, M. Wuhrer, R. Geyer, G. Baljer, and C. Menge (2002)
Bovine lymphocytes express functional receptors for Escherichia coli Shiga toxin 1.
Microbial Path. 33(6):251-264

Menge, C., Ivonne Stamm, Maike Blessenohl, L.H. Wieler, and G. Baljer (2003)
Verotoxin 1 from Escherichia coli affects Gb3/CD77+ bovine lymphocytes independent of interleukin-2, tumor necrosis factor-alpha, and interferon-alpha. Exp. Biol. Med. 228:377-386

Tyczka, Judith, Wiebke Maaß, Cornelie Jäger, C. Menge, and G. Baljer (2003)
Differences in cytokine mRNA profiles betwen naive and in vivo-primed ovine PBMC after exposition to heat-inactivated Coxiella burnetii. Ann. N.Y. Acad. Sc. 990:460-467

Menge, C. (2003)
Protocols to study effects of Shiga toxin on mononuclear leukocytes.
In D.J. Philpott and F. Ebel. Methods in Molecular Medicine: Shiga-toxin producing Escherichia coli: Methods and Protocols. Humana Press Inc., Totowa, N.J., 73:275-89

Ewers, Christa, C. Schüffner, R. Weiß, G. Baljer, and L.H. Wieler (2004)
Molecular characteristics of Escherichia coli serogroup O78 isolated from diarrheal cases in bovines urge further investigations on their zoonotic potential. Mol. Nutr. Food. Res., 48, 504-514

Menge, C., Maike Blessenohl, Ivonne Stamm, and G. Baljer (2004)
Bovine ileal intraepithelial lymphocytes represent target cells for Shiga toxin 1 from Escherichia coli.
Infect. Immun. 72(4):1896-1905

Menge, C., Ivonne Stamm, Pauline M. van Diemen, P. Sopp, G. Baljer, T. S. Wallis, and M. P. Stevens (2004) Phenotypic and functional characterisation of intraepithelial lymphocytes in a bovine ligated intestinal loop model of enterohaemorrhagic Escherichia coli infection.
J. Med. Microbiol. 53(6):573-579

Ewers, Christa, C. Schüffner, R. Weiß, G. Baljer, and L.H. Wieler (2004)
Molecular characteristics of Escherichia coli serogroup O78 strains isolated from diarrheal cases in bovines urge further investigations on their zoonotic potential. Mol. Nutr. Food Res. 48(7):504-514

Lühken, Gesine, Ivonne Stamm, C. Menge, and G. Erhardt (2005)
Functional analysis of a single nucleotide polymorphism in a potential binding site for GATA transcription factors in the ovine interleukin 2 gene. Vet. Immunol. Immunopathol. 107:51-56

Grossmann, K., B. Weniger, G. Baljer, B. Brenig, and L.H. Wieler (2005)
Racing, ornamental and city pigeons carry Shiga toxin producing Escherichia coli (STEC) with different Shiga toxin subtypes, urging further analysis of their epidemiological role in the spread of STEC. BMTW 118, 456-463

Schoepe, Heike, A. Neubauer, T. Schlapp, L.H. Wieler, and G. Baljer (2005)
Immunization with an alphatoxin variant 121A/91 - R212H protects nice against C. perfringens alphatoxin. Anaerobe 12, 44-48

Menge, C., T. Eisenberg, Ivonne Stamm, and G. Baljer (2006)
Comparison of binding and effects of Escherichia coli Shiga toxin 1 on bovine and ovine granulocytes. Vet. Immunol. Immunopathol.113:392-403

Moussay, E., Ivonne Stamm, Anja Taubert, G. Baljer, and C. Menge (2006)
Escherichia coli Shiga toxin 1 enhances il-4 transcripts in bovine ileal intraepithelial lymphocytes.
Vet. Immunol. Immunopathol. 113:367-382

<< zurück | ^ Seitenanfang  
TP A12

Savvides SN, Scheiwein M, Boehme CC, Arteel GE, Karplus PA, Becker K & Schirmer RH (2002)
Crystal structure of the antioxidant enzyme glutathione reductase inactivated by peroxynitrite
J Biol Chem 277: 2779-2784

Kanzok S, Rahlfs S, Becker K & Schirmer RH (2002)
Thioredoxin, thioredoxin reductase, and thioredoxin peroxidase of the malaria parasite
Plasmodium falciparum
Meth Enzymol 347: 370-381

Rahlfs S, Schirmer RH & Becker K (2002)
The thioredoxin system of Plasmodium falciparum and other parasites
Cell Mol Life Sci 59: 1024-1041

Harwaldt P, Rahlfs S, Becker K (2002)
Glutathione S-transferase of the malarial parasite Plasmodium falciparum. Characterization of a potential drug target
Biol Chem 383: 821-830

Becker K, Kanzok SM, Iozef R, Fischer M, Schirmer RH & Rahlfs S (2003)
Plasmoredoxin – a novel redox-active protein unique for malarial parasites (priority paper)
Eur J Biochem 270: 1057-1064

Sarma GN, Savvides SN, Becker K, Schirmer M, Schirmer RH & Karplus PA (2003)
Glutathione reductase of the malarial parasite Plasmodium falciparum: Crystal structure and inhibitor development
J Mol Biol 308: 893-907

Davioud-Charvet E, McLeish MJ, Veine DM, Giegel D, Arscott LD, Andricopulo AD, Becker K, Muller S, Schirmer RH, Williams CH Jr, Kenyon GL (2003)
Mechanism-based inactivation of thioredoxin reductase from Plasmodium falciparum by Mannich Bases. Implication for cytotoxicity
Biochemistry 42: 13319-13330

Rahlfs S, Nickel C, Deponte M, Schirmer RH & Becker K (2003)
Plasmodium falciparum thioredoxins and glutaredoxins as central players in redox metabolism
Redox Report 8: 246-250

Becker K, Tilley L, Vennerstrom JL, Roberts D, Rogerson S, Ginsburg H (2004)
Oxidative stress in malaria parasite-infected erythrocytes: host-parasite interactions
Int J Parasitol 34: 163-189

Becker K & Kirk K (2004)
Of malaria, metabolism, and membrane transport
Trends Parasitol 20: 590-596

Sarma G, Nickel C, Rahlfs S, Fischer M, Becker K & Karplus PA (2005)
Crystal structure of a novel Plasmodium falciparum 1-Cys-peroxiredoxin
J Mol Biol 346: 1021-1034

Deponte M & Becker K (2005)
Biochemical characterization of Toxoplasma gondii 1-Cys peroxiredoxin 2 with mechanistic similarities to typical 2-Cys Prx
Mol Biochem Parasitol, 140: 87-96

Nickel C, Trujillo M, Rahlfs S, Deponte M, Radi R & Becker K (2005)
Plasmodium falciparum 2-Cys peroxiredoxin reacts with plasmoredoxin and peroxynitrite.
Biol Chem 386: 1129-36.

Hiller N, Fritz-Wolf K, Deponte M, Wende W, Zimmermann H & Becker K (2006)
Plasmodium falciparum glutathione S-transferase – structural and mechanistic studies on ligand binding and enzyme inhibition
Protein Science, 15:241-254

Rahlfs S & Becker K (2006)
Interference with redox-active enzymes as a basis for the design of antimalarial drugs
Mini Rev Med Chem, 6:163-176

<< zurück | ^ Seitenanfang  
TP A13


Kolesnikova, L., B. Berghöfer, S. Bamberg, and S. Becker. 2004. Multivesicular Bodies as a Platform for Formation of the Marburg Virus Envelope. J. Virol. 78:12277-12287.

Kolesnikova, L., S. Bamberg, B. Berghöfer, and S. Becker. 2004. The matrix protein of Marburg virus is transported to the plasma membrane along cellular membranes: exploiting the retrograde late endosomal pathway. J. Virol. 78:2383-93.

Traggiai, E., S. *Becker, K. *Subbarao, L. Kolesnikova, Y. Uematsu, M. R. Gismondo, B. R. Murphy, R. Rappuoli, and A. Lanzavecchia. 2004. An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus. Nature Med. 10:871-875 *: equal contributors.

Drosten, C., S. Günther, W. Preiser, S. van der Werf, H. R. Brodt, S. Becker, H. Rabenau, M. Panning, L. Kolesnikova, R. A. Fouchier, A. Berger, A. M. Burguiere, J. Cinatl, M. Eickmann, N. Escriou, K. Grywna, S. Kramme, J. C. Manuguerra, S. Muller, V. Rickerts, M. Sturmer, S. Vieth, H. D. Klenk, A. D. Osterhaus, H. Schmitz, and H. W. Doerr. 2003. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med 348:1967-76.

Eickmann, M., S. Becker, H. D. Klenk, H. W. Doerr, K. Stadler, S. Censini, S. Guidotti, V. Masignani, M. Scarselli, M. Mora, C. Donati, J. H. Han, H. C. Song, S. Abrignani, A. Covacci, and R. Rappuoli. 2003. Phylogeny of the SARS coronavirus. Science 302:1504-5.

Hartlieb, B., J. Modrof, E. Mühlberger, H.-D. Klenk, and S. Becker. 2003. Oligomerization of Ebola virus VP30 is essential for viral transcription and can be inhibited by a synthetic peptide. J. Biol. Chem. 278:41830-6.

Kolesnikova, L., Bugany, H., Klenk, H.-D., and Becker, S. 2002. VP40, the matrix protein of Marburg virus, is associated with membranes of the late endosomal compartment. J. Virol. 76: 1825-1838.

Modrof, J., Klenk, H. D., Mühlberger, E., and Becker, S. Phosphorylation of VP30 impairs transcription of Ebola virus J. Biol. Chem. 277: 33099-104.

Sänger, C., E. Mühlberger, E. Ryabchikova, L. Kolesnikova, H.-D. Klenk, and S. Becker. (2001) Release of Marburg virus surface protein GP and budding of infectious virions take place at opposite surfaces of polarized epithelial cells. J. Virol. 75: 1274-1283.

Kolesnikova, L., E. Mühlberger, E. Ryabchikova, and S. Becker. (2000) Ultrastructural organization of the recombinant nucleoprotein of Marburg virus: Comparison with Marburg viral inclusions. J. Virol. 74: 3899-3904.

<< zurück | ^ Seitenanfang  
TP A15

1. Wuhrer, M., Berkefeld, C., Dennis, R.D., Idris, M.A., and Geyer, R. (2001). Liver flukes Fasciola gigantica and Fasciola hepatica express the leukocyte cluster of differentiation marker CD77 (globotriaosylceramide) in their tegument. Biol. Chem., 382, 195-207.

2. Wuhrer, M., Kantelhardt, S.R., Dennis, R.D., Doenhoff, M.J., Lochnit, G., and Geyer, R. (2002). Characterization of glycosphingolipids from Schistosoma mansoni eggs carrying Fuc(?1-3)GalNAc-, GalNAc(?1-4)[Fuc(?1-3)]GlcNAc- and Gal(?1-4)[Fuc(?1-3)]GlcNAc- (Lewis X) terminal structures. Eur.
J. Biochem., 269, 481-493.

3. Schmitt, J., Wuhrer, M., Geyer, R., Hamburger, J., Jourdane, J., Ramzy, R.M.R., and Ruppel, A. (2002). Schistosoma mansoni and S. haematobium: Identification and characterization of glycoconjugate antigens in the haemolymph of infected vector snails. J. Parasitol., 88, 505-513.

4. Kantelhardt, S.R., Wuhrer, M., Dennis, R.D., Doenhoff, M.J., Bickle, Q., and Geyer, R. (2002). Fuc(a1-3)GalNAc-: major antigenic motif of Schistosoma mansoni glycolipids implicated in infection sera and keyhole limpet haemocyanin cross-reactivity. Biochem. J., 366, 217-223.

5. Wuhrer, M., Grimm, C., Zähringer, U., Dennis, R.D., Berkefeld, C.M., Idris, M.A., and Geyer, R. (2003). A novel GlcNAca1-HPO3-6Gal(1-1)ceramide antigen and alkylated inositol-phosphoglycerolipids expressed by the liver fluke Fasciola hepatica. Glycobiology, 13, 129-137.
6. Wuhrer, M., Grimm, C., Dennis, R.D., Idris, M.A., and Geyer, R. (2004). The parasitic trematode Fasciola hepatica exhibits mammalian-type glycolipids as well as Gal(ß1-6)Gal-terminating glycolipids that account for cestode serological cross-reactivity. Glycobiology, 14, 115-126.

7. Robijn, M.L.M., Wuhrer, M., Kornelis, D., Deelder, A.M., Geyer, R., and Hokke, C.H. (2005). Mapping fucosylated epitopes on glycoproteins and glycolipids of Schistosoma mansoni cercariae, adult worms and eggs. Parasitology, 130, 67-77.

8. Geyer, H., Wuhrer, M., Resemann, A., and Geyer, R. (2005). Identification and characterization of keyhole limpet hemocyanin (KLH) N-glycans mediating cross-reactivity with Schistosoma mansoni. J. Biol. Chem., 280, 40731-40748.

9. Meyer, S., van Liempt, E., Imberty, A., van Kooyk, Y, Geyer, H., Geyer, R., and van Die, I. (2005). DC-SIGN mediates binding of dendritic cells to authentic pseudo-LewisY glycolipids of Schistosoma mansoni cercariae – the first parasite-specific ligand of DC-SIGN. J. Biol. Chem., 280, 37349-37359.

<< zurück | ^ Seitenanfang  
TP A17

Diederich, S., Moll., M., H.-D. Klenk, and A. Maisner (2005). The Nipah virus fusion protein is cleaved within the endosomal compartment. J. Biol. Chem. 280:29899-903.

Vogt, C., Eickmann, M., Diederich, S., Moll, M., and A. Maisner (2005). Endocytosis of the Nipah virus glycoproteins. J. Virol. 79:3865-3872.

Moll, M., Diederich, S., Klenk, H.-D., Czub, M., and A. Maisner (2004). Ubiquitous activation of the Nipah virus fusion protein does not require a basic amino acid at the cleavage site. J. Virol. 78:9705-9712.

Moll, M., Pfeuffer, J., Klenk, H.-D., Niewiesk, S., and A. Maisner (2004). Polarized glycoprotein targeting affects spread of measles virus in vitro and in vivo. J. Gen. Virol., 85:1019-1027.
Moll, M., Kaufmann, A. and A. Maisner (2004). Influence of N-glycans on the processing and the biological activity of the Nipah virus fusion protein. J.Virol. 78:7274-7278.

Moll, M., Klenk, H.-D., and A. Maisner (2002). Importance of the cytoplasmic tails of the measles virus glycoproteins for fusogenic activity and the generation of recombinant measles viruses. J. Virol. 76:7174-7186.

Riedl, P., Moll, M., Klenk, H.-D., and A. Maisner (2002). Measles virus matrix protein is not cotransported with the viral glycoproteins but requires virus infection for efficient surface targeting. Virus Res. 83:1-12.

Moll, M., H.-D. Klenk, G. Herrler, and A. Maisner (2001). A single amino acid change in the cytoplasmic domains of measles virus glycoproteins H and F alters targeting, endocytosis and fusion in polarized MDCK cells. J. Biol. Chem. 276:17887-17894.

Maisner, A., B. Mrkic, G. Herrler, M. Moll, M. A. Billeter, R. Cattaneo and H.-D. Klenk (2000). Recombinant measles virus requiring an exogenous protease for activation of infectivity. J. Gen. Virol. 81:441-449.

Weidmann, A., A. Maisner, W. Garten, M. Seufert, V. ter Meulen, and S. Schneider-Schaulies. (2000). Proteolytic cleavage of the fusion protein but not membrane fusion is required for measles virus-induced immunosuppression in vitro. J. Virol. 74:1985-1993.

<< zurück | ^ Seitenanfang  
TP A18

Kim, K. H., Rumenapf, T., Strauss, E. G., and Strauss, J. H. (2004). Regulation of Semliki Forest virus RNA replication: a model for the control of alphavirus pathogenesis in invertebrate hosts. Virology 323(1), 153-63.

Maurer, K., Krey, T., Moennig, V., Thiel, H.-J., and Rümenapf, T. (2004). CD46 is a cellular receptor for bovine viral diarrhea virus. J Virol 78(4), 1792-9.

Hausmann, Y., Roman-Sosa, G., Thiel, H. J., and Rumenapf, T. (2004). Classical swine fever virus glycoprotein E rns is an endoribonuclease with an unusual base specificity. J Virol 78(10), 5507-12.

Gallei, A., Rumenapf, T., Thiel, H. J., and Becher, P. (2005). Characterization of helper virus-independent cytopathogenic classical swine fever virus generated by an in vivo RNA recombination system. J Virol 79(4), 2440-8.

Krey, T., Thiel, H.-J., and Rümenapf, T. (2005). Acid-Resistant Bovine Pestivirus Requires Activation for pH-Triggered Fusion during Entry. J Virol 79(7), 4191-200.

Heimann, M., Sosa, G. R., Martoglio, B., Thiel, H. J. & Rumenapf, T. (2006). Core protein of estiviruses is processed at the C terminus by signal Peptide peptidase. J Virol 80, 1915-21.

Krey, T., Himmelreich, A., Heimann, M., Menge, C., Thiel, H. J., Maurer, K. & Rumenapf, T. (2006). Function of Bovine CD46 as a Cellular Receptor for Bovine Viral Diarrhea Virus Is Determined by Complement Control Protein 1. J Virol 80, 3912-22. T.K. and A.H. contributed equally to this work.

<< zurück | ^ Seitenanfang  

Song Y, Tzima E, Ochs K, Bassili G, Trusheim H, Linder M, Preissner KT, and Niepmann M. 2005.
Evidence for an RNA chaperone function of polypyrimidine tract-binding protein in picornavirus translation.
RNA 11, 1809-1824.

Nakazawa F, Kannemeier C, Shibamiya A, Song Y, Tzima E, Schubert U, Koyama T, Niepmann M, Trusheim H, Engelmann B, and Preissner KT. 2005.
Ectracellular ribonucleic acid (RNA) is a natural cofactor for the (auto-)activation of factor VII-activating protease (FSAP).
Biochem. J. 385, 831-838.

Altincicek B, Shibamiya A, Trusheim H, Tzima E, Niepmann M, Linder D, Preissner KT, and Kanse S.
Characterisation of the interaction of factor VII activating protease (FSAP) with ribonucleic acid.
Biochem. J., Online-Publication Dec. 6th, 2005.

Bassili G, Tzima E, Song Y, Saleh Y, Ochs K, and Niepmann M. 2004.
A highly conserved sequence element of the foot-and-mouth disease virus internal ribosome entry site is essential for interaction with eIF4G and for translation.
J. gen. Virol. 85, 2555-2565.

Niepmann M. 2003.
Effects of potassium and chloride on ribosome association with the RNA of foot-and-mouth-disease virus.
Virus Res., 93(1), 71-78.

Boussadia O, Niepmann M, Créancier L, Prats A-C, Dautry F, and Jacquemin-Sablon H. 2003.
Unr is required in vivo for efficient initiation of translation from the internal ribosome entry sites of both rhinovirus and poliovirus.
J. Virol. 77, 3353-3359.

Ochs K, Zeller A, Saleh L, Bassili G, Song Y, Sonntag A, and Niepmann M. 2003.
Impaired binding of standard initiation factors mediates poliovirus translation attenuation.
J. Virol. 77:115-122.

Ochs K, Saleh L, Bassili G, Sonntag VH, Zeller A, and Niepmann M. 2002.
Interaction of translation initiation factor eIF4B with the poliovirus internal ribosome entry site.
J. Virol. 76:2113-2122.

Saleh L, Rust R.C, Füllkrug R, Beck E, Bassili G, Ochs K, and Niepmann, M. 2001.
Functional interaction of translation initiation factor eIF4G with the foot-and-mouth disease virus internal ribosome entry site.
J. Gen. Virol. 82:757-763.

<< zurück | ^ Seitenanfang  

Rinck, G., C. Birghan , T. Harada, G. Meyers , H.-J. Thiel, and N. Tautz. 2001. A cellular J-domain protein modulates polyprotein processing and cytopathogenicity of a pestivirus. J. Virol. 75: 9470-9482.

Tautz, N. and H.-J. Thiel. 2003. Functional importance of the N terminus of NS3 for replication of pestiviruses. Arch. Virol. 148: 1405-12.

Müller A., G. Rinck, H.-J. Thiel, and N. Tautz. 2003. Cell-derived sequences located in the structural genes of a cytopathogenic pestivirus. J. Virol. 77: 10663-10669.

Lackner T., A. Müller, A. Pankraz, P. Becher, H.-J. Thiel, A.E. Gorbalenya, and N. Tautz. 2004. Temporal modulation of an autoprotease is crucial for replication and pathogenicity of an RNA virus. J. Virol. 78:10765-10775.

Tautz, N., H.-J. Thiel. 2004. Pestivirus NS2-3/NS3 serine peptidase. In A.J. Barrett an N. D. Rawlings and J.F. Woessner (ed.), Handbook of proteolytic enzymes. Second Edition. Academic Press, p. 1781-1784.

Lackner T., A. Müller, M. König, H.-J. Thiel, and N. Tautz. 2005. Persistence of bovine viral diarrhea virus is determined by a cellular cofactor of a viral autoprotease. J. Virol. 79: 9746-9755.

Lackner T., H.-J. Thiel, and N. Tautz. 2006. Dissection of a viral autoprotease elucidates a function of a cellular chaperone in proteolysis. PNAS, 103:1510-1515.

<< zurück | ^ Seitenanfang  

Whittaker G, Kann M and Helenius A. 2000. Viral Entry into the Nucleus (Review). Annu Rev Cell Dev Biol 16:627-51

Kann M. 2000. Delivering the goods: how a viral genome transfers from the virus to the nucleus. (Minireview). The ELSO Gazette: e-magazine of the European Life Scientist Organization (http://www.the-elso-gazette/magazines/issue1/mreviews/mreviews1.asp), Issue 2 (6 November, 2000)

Burrell CJ, Chisari FV, Gerlich WH, Gowans EJ, Howard CR, Kann M and Marion PL. 2000. Hepadnaviridae, in Virus Taxonomy, M.H.V. van Regenmortel et al. (ed), Academic Press, San Diego. pp 325-334

Muth H, Elmshauser C, Broad S, Watt F, Schipke C, Kettenman H, Trotter J, Kann M, Motta I, Schimpl A, Beck E and Chen U. 2001. Conditional immortalization and partial cellular characterization of a doxycycline-inducible oligodendrocyte precursor cell line in vitro. J Gene Med 3(6):585-98

Panté N and Kann M. 2002. The Nuclear Pore Complex is Able to Transport Macromolecules with Diameters of ?39 nm. Mol Biol Cell. 13(2):425-34.

Wolff T, Unterstab G, Heins G, Richt JA, and Kann M. 2002. Characterization of an unusual importin a binding motif in the Borna disease virus p10 protein which directs nuclear import J. Biol. Chem. 277(14):12151-12157

Elmshauser C, Bechtel J, Motta I, Schipke C, Kettenmann H, Schmalbruch H, Kann M, Beck E, Chen U. 2002. Characterization of a mouse tet-on glia precursor cell line in vitro and in vivo using the electrophysiological measurement. J Physiol Paris. 2002 May-Aug;96(3-4):329-38.

Lischka P, Sorg G, Kann M, Winkler M and Stamminger T. 2003. A non-conventional nuclear localization signal within the UL84-protein of human cytomegalovirus mediates nuclear import via the importin ?/?-pathway. J Virol 77(6): 3734-48

Kann M. 2002. Chapter 2. Structural and Molecular Biology. In: Hepatitis B Virus Guide. S. Locarnini and C.L.Lai (eds). pp 9-22. London, Atlanta: International Medical Press Ltd.

Jilbert A, Burrell CJ, Triyatni M, Kann M. 2002. Chapter 4. Hepatitis B Virus Replication. In: Hepatitis B virus Human Virus Guide. S. Locarnini and C.L.Lai (eds). pp 43-54. London, Atlanta: International Medical Press Ltd.

Köck J, Kann M, Pütz G, Blum HE, von Weizsäcker F. 2003. Regulation of duck hepatitis B virus capsid trafficking and targeted genome release by core protein phosphorylation. J Biol Chem; 278(30):28123-9

Rabe B, Vlachou A, Panté N, Helenius A, Kann M. 2003. Nuclear Import of Hepatitis B Virus Capsids and Genome. Proc Natl Acad Sci U.S.A. 100 (17): 9849-9854(recommended by the Faculty of 1000: evaluations for Rabe B et al Proc Natl Acad Sci U S A 2003 Aug 19 100 (17) :9849-54

Isken O, Grassmann CW, Sarisky RT, Kann M, Zhang S, Grosse F, Kao PN, Behrens SE. 2003. Members of the NF90/NFAR protein group are involved in the life cycle of a positive-strand RNA virus. EMBO J Nov 3; 22 (21): 5655-5665

Kann M. 2004. Nucleoprotein Transport of HBV Capsid Particles. Methods Mol Med. 2004:213-226
Kann M. 2004. Interfering with capsid formation: a practicable antiviral strategy against hepatitis B virus? Hepatology, Mar;39(3):838-40

Gerlich WH and Kann M. 2005. Structure and Molecular Virology. In: Viral Hepatitis. Zuckerman AJ and Thomas HC (eds). Edinburgh, London, Madrid, Melbourne, New York, Tokyo: Churchill Livingston.149-180

Gerlich WH and Kann M. 2005. Hepatitis B. In: Topley & Wilson´s Microbiology and Microbial Infections. 9th edition. Collier L, Balows A, Sussman M (eds). Edward Arnold (Publishers) Ltd., London, U.K.:1226-1268

Rösler C, Köck J, Kann M, Malim MH, Blum HE, Baumert TF, von Weizsäcker F. 2005. APOBEC-mediated Interference with Hepadnavirus Production. Hepatology, Aug;42(2):301-9.

Damianov A, Kann M, Lane WS and Bindereif A. The human RBM28 protein is a specific nucleolar component of the spliceosomal snRNPs. Biol Chem 2006; accepted

Rabe B, Glebe D, Kann M. Lipid-mediated entry of hepatitis B virus capsids in non-siscetible cells allows hoighly efficient replication and the analysis of the early infection events. J Virol 2006; 80(11):5465-5473

Michael Kann, André Schmitz and Birgit Rabe. Intracellular transport of the hepatitis B virus. World Journal of Hepatitis 2006; accepted

<< zurück | ^ Seitenanfang  

Becher, P., M. Orlich, and H.-J. Thiel. 2000. Mutations in the 5´ nontranslated region of bovine viral diarrhea virus result in altered growth characteristics. Journal of Virology 74: 7884-7894.

Baroth, M., M. Orlich, H.-J. Thiel, and P. Becher. 2000. Insertion of cellular NEDD8 coding sequences in a pestivirus. Virology 278: 456-466.

Becher, P., M. Orlich, and H.-J. Thiel. 2001. RNA recombination between persisting pestivirus and a vaccine strain: generation of cytopathogenic virus and induction of lethal disease. Journal of Virology 75: 6256-6264.

Avalos-Ramirez, R., M. Orlich, H.-J. Thiel, and P. Becher. 2001. Evidence for the presence of two novel pestivirus species. Virology 286: 456-465.

Becher, P., H.-J. Thiel, M. Collins, J. Brownlie & M. Orlich. 2002. Cellular sequences in pestivirus genomes encoding gamma-aminobutyric acid (A) receptor-associated protein and golgi-associated ATPase enhancer of 16 kilodaltons. Journal of Virology 76: 13069-13076.

Becher, P. and H.-J. Thiel. 2002. Genus Pestivirus (Flaviviridae). In “Springer index of viruses“, pp. 327-331. Edited by C. A. Tidona and G. Darai. Springer Verlag, Heidelberg, Germany.

Becher, P., R. Avalos Ramirez, M. Orlich, S. Cedillo Rosales, M. König, M. Schweizer, H. Stalder, H. Schirrmeier, and H.-J. Thiel. 2003. Genetic and antigenic characterization of novel pestivirus genotypes: implications for classification. Virology 311: 96-104.

Gallei, A., A. Pankraz, H.-J. Thiel, and P. Becher. 2004. RNA recombination in vivo in the absence of viral replication. Journal of Virology 78: 6271-6281.

Makoschey, B., P. Becher, M. G. J. Janssen, M. Orlich, H.-J. Thiel, and D. Lütticken. 2004. Bovine viral diarrhea virus with deletions in the 5'-nontranslated region: reduction of replication in calves and induction of protective immunity. Vaccine 22: 3285-3294.

Lackner, T., A. Müller, A. Pankraz, P. Becher, H.-J. Thiel, A.E. Gorbalenya, and N. Tautz. 2004. Temporal modulation of an autoprotease is crucial for replication and pathogenicity of an RNA virus. Journal of Virology 78: 10765-10775.

Gallei, A., T. Rümenapf, H.-J. Thiel, and P. Becher. 2005. Characterization of helper virus independent cytopathogenic classical swine fever virus generated by an in vivo RNA recombination system. Journal of Virology 79: 2440-2448.

Pankraz, A., H.-J. Thiel, and P. Becher (2005). Essential and nonessential elements in the 3' nontranslated region of bovine viral diarrhea virus. Journal of Virology 79: 9119-9127.

Gallei, A., M. Orlich, H.-J. Thiel, and P. Becher (2005). Noncytopathogenic pestivirus strains generated by nonhomologous RNA recombination: alterations in the NS4A/NS4B coding region. Journal of Virology 79: 14261-14270.

Choi, K. H., A. Gallei, P. Becher, and M. G. Rossmann (2006). The structure of bovine viral diarrhea virus RNA-dependent RNA polymerase and its amino terminal domain. Structure 14: 1107- 1113.

Gallei, A., S. Widauer, H.-J. Thiel, and P. Becher (2006). Mutations in the palm region of a plus-strand RNA virus polymerase result in attenuated phenotype. Journal of General Virology 87: 3631-3636.

<< zurück | ^ Seitenanfang  

Enterlein, S., Volchkov, V., Weik, M:, Kolesnikova, L., Volchkova, V., Klenk, H.-D., and Mühlberger, E. 2006. Rescue of recombinant Marburg virus from cDNA is dependent on the nucleocapsid protein VP30. J. Virol. 80: 1038-1043.

Kash, J. C.*, Mühlberger, E.*, Carter, V., Grosch, M., Proll, S., Thomas, M., Weber, F., Klenk, H.-D., and and Katze, M. G. 2006. Global suppression of the host anti-viral response by Ebola and Marburg viruses. J. Virol. 80: 3009-3020. * equal contribution.

Enterlein, S., Warfield, K. L., Swenson, D. L., Stein, D. A., Smith, J. L., Gamble, C. S., Kroeker, A. D., Iversen, P. L., Bavari, S., and Mühlberger, E. 2006. VP35 knockdown inhibits ebolavirus amplification and protects against lethal infection in mice. Antimicrob. Agents Chemother. 50: 984-993.

Weik, M., Enterlein, S., Schlenz, K., and Mühlberger, E. 2005. The Ebola virus genomic replication promoter is bipartite and follows the rule of six. J. Virol. 79: 10660-10671.

Boehmann, Y., Enterlein, S., Randolf, A, and Mühlberger, E. 2005. A reconstituted replication and transcription system for Ebola virus Reston and comparison with Ebola virus Zaire. Virology 332: 406-417.

Weidmann, M., Mühlberger, E., and Hufert, F. T. 2004. Rapid detection protocol for filoviruses J. Clin. Virol. 30: 94-99.

Modrof, J., Becker, S., and Mühlberger, E. 2003. The Ebola virus transcription activator VP30 is a zinc-binding protein. J. Virol. 77: 3334-3338.

Hartlieb, B., Modrof, J., Mühlberger, E., Klenk, H.-D., and Becker, S. 2003. Oligomerization of Ebola virus VP30 is essential for viral transcription and can be inhibited by a synthetic peptide. J. Biol. Chem. 278: 41830-41836.

Basler, C. F., Mikulasova, A., Martinez-Sobrido, L., Paragas, J., Mühlberger, E., Bray, M., Klenk, H.-D., Palese, P., and Garcia-Sastre, A. 2003. The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3. J. Virol. 77: 7945-7956.

Weik, M., Modrof, J., Klenk, H.-D., Becker, S., and Mühlberger, E. 2002. Ebola virus VP30-mediated transcription is regulated by RNA secondary structure formation. J. Virol. 76: 8532-8539.

Modrof, J., Mühlberger, E., Klenk, H.-D., and Becker, S. 2002. Phosphorylation of VP30 impairs Ebola virus transcription. J. Biol. Chem. 277: 33099-104.

Volchkov, V. E., Volchkova, V. A., Mühlberger, E., Kolesnikova, L. V., Weik, M., Dolnik, O., and Klenk, H.-D. 2001. Recovery of infectious Ebola virus from complementary DNA: RNA editing of the GP gene and viral cytotoxicity. Science 291: 1965-1969.

Modrof, J., Möritz, C., Kolesnikova, L., Konakova, T., Hartlieb, B., Randolf, A., Mühlberger, E., and Becker, S. 2001. Phosphorylation of Marburg virus VP30 at serines 40 and 42 is critical for its interaction with NP inclusions. Virology 287: 171-182.

<< zurück | ^ Seitenanfang  
TP B10

Damianov, A., Kann, M., Lane, W.S., and Bindereif, A. (2006). The human RBM28 protein is a specific nucleolar component of the spliceosomal snRNPs. Biological Chemistry, in press.

Hui, J., Hung, L.-H., Heiner, M., Schreiner, S., Neumüller, N., Reither, G., Haas, S.A., and Bindereif, A. (2005). Intronic CA-repeat and CA-rich elements: a new class of regulators of mammalian alternative splicing. EMBO J. 24, 1988-1998.

Hui, J. and Bindereif, A. (2005). Alternative pre-mRNA splicing in the human system: Unexpected role of repetitive sequences as regulatory elements. Biological Chemistry 386, 1265-1271.

Lücke, S., Jürchott, K., Hung, L.-H., and Bindereif, A. (2005). mRNA splicing in Trypanosoma brucei: Branch-point mapping reveals differences from the canonical U2 snRNA-mediated recognition. Mol. Biochem. Parasitol. 142, 248-251.

Palfi, Z., Schimanski, B., Günzl, A., Lücke, S., and Bindereif, A. (2005). U1 small nuclear RNP from Trypanosoma brucei: a minimal U1 snRNA with unusual protein components. Nucleic Acids Res. 33, 2493-2503.

Medenbach, J., Damianov, A., Schreiner, S., and Bindereif, A. (2005). Sedimentation analysis of ribonucleoprotein complexes. In Handbook of RNA biochemistry (E. Westhof, A. Bindereif, A. Schön, and R.K. Hartmann, eds.; Wiley-VCH), p. 428-437.

Palfi, Z., Hui, J., and Bindereif, A. (2005). Biotin-based affinity purification of RNA-protein complexes. In Handbook of RNA biochemistry (E. Westhof, A. Bindereif, A. Schön, and R.K. Hartmann, eds.; Wiley-VCH), p. 676-693.

Medenbach, J., Schreiner, S., Liu, S., Lührmann, R., and Bindereif, A. (2004). Human U4/U6 snRNP recycling factor p110: mutational analysis reveals function of TPR domain in recycling. Mol. Cell. Biol. 24, 7392-7401.

Damianov, A., Schreiner, S., and Bindereif, A. (2004). Recycling of the U12-type spliceosome requires p110, a component of the U6atac snRNP. Mol. Cell. Biol. 24, 1700-1708.

Hui, J., Reither, G., and Bindereif, A. (2003). Novel functional role of CA repeats and hnRNP L in RNA stability. RNA 9, 931-936.

Hui, J., Stangl, K., Lane, W.S., and Bindereif, A. (2003). HnRNP L stimulates splicing of the eNOS gene by binding to variable-length CA repeats. Nature Struct. Biol. 10, 33-37.

Bell, M., Schreiner, S., Damianov, A., Reddy, R., and Bindereif, A. (2002). p110, a novel human U6 snRNP protein and U4/U6 snRNP recycling factor. EMBO J. 21, 2724-2735.

Palfi, Z., Lane, W.S., and Bindereif, A. (2002). Biochemical und functional characterization of the cis-spliceosomal U1 small nuclear RNP from Trypanosoma brucei. Mol. Biochem. Parasitol. 121, 233-243.

Günzl, A., Palfi, Z., and Bindereif, A. (2002). Analysis of RNA-protein complexes by oligonucleotide-targeted RNase H digestion. Methods 26, 162-169.

Woerfel, G. and Bindereif, A. (2001). In vitro selection of exonic splicing enhancer sequences: Identification of novel CD44 enhancers. Nucleic Acids Res. 29, 3204-3211.

Stangl, K., Cascorbi, I., Laule, M., Klein, T., Stangl, V., Rost, S., Wernecke, K.D., Felix, S.B., Bindereif, A., Baumann, G., and Roots, I. (2000). High CA repeat numbers in intron 13 of the endothelial nitric oxide synthase gene and increased risk of coronary artery disease. Pharmacogenetics 10, 133-140.

Bell, M., Wöhner, R.-V., and Bindereif, A. (2000). Trans spliceosomal U4 snRNA genes of trypanosomes: Cloning of the Leptomonas seymouri gene, phylogenetic comparison, and mutational analysis of core snRNP assembly. Gene 247, 77-86.

Günzl, A., Bindereif, A., Ullu, E., and Tschudi, C. (2000). Determinants for cap trimethylation of the U2 small nuclear RNA are not conserved between Trypanosoma brucei and higher eukaryotic organisms. Nucleic Acids Res. 28, 3702-3709.

Palfi, Z., Lücke, S., Lahm, H.-W., Lane, W.S., Kruft, V., Bragado-Nilsson, E., Séraphin, B., and Bindereif, A. (2000). The spliceosomal snRNP core complex of Trypanosoma brucei: Cloning and functional analysis reveals seven Sm protein constituents. Proc. Natl. Acad. Sci. USA 97, 8967-8972.

<< zurück | ^ Seitenanfang  
TP B12

Hamdorf, M., Muckenfuss, H., Tschulena, U., Pleschka, S., Sanzenbacher, R., Cichutek, K., Flory, E. 2006. An inducible T7 RNA polymerase-dependent plasmid system. Mol Biotechnol. 33(1):13-21

Marjuki, H., Alam, M.I., Ehrhardt, C., Wagner, R., Planz, O., Klenk, H.-D., Ludwig, Pleschka, S. 2006. Membrane accumulation of Influenza A virus hemagglutinin triggers nuclear export of the viral genome via PKC-alpha mediated activation of ERK signalling. 2006. J Biol Chem., in press, e-published ahead of print

Ehrhardt, C., Marjuki, H., Wolff, T., Nürnberg, B., Planz, O., Pleschka, S. and Ludwig, S. 2006. Bivalent role of PI3K during influenza virus infection and host cell defense. Cell. Micro Biol., in press

Bourteele, S., Oesterle, K., Pleschka, S., Unterstab, G., Ehrhardt, C., Wolff, T., Ludwig, S., Planz, O. 2005. Constitutive activation of the transcription factor NF-kappaB results in impaired borna disease virus replication. J Virol. May;79(10):6043-51.

Ölschläger, V., Pleschka, S., Fischer, T., Wurzer, W., Stitz, L.,Rapp, U.R., Ludwig, S., and Planz, O. 2004. Increased mortality after influenza A virus infection of mice expressing active Raf kinase in the lung. Oncogene, Aug 26;23(39):6639-46.

Wurzer, W.J., Erhardt, C., Pleschka, S., Berberich-Seibelt, F., Wolff, T., Walczak, H., Planz, O. and Ludwig, S. 2004. NF-kappaB-dependent of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas/FasL is crucial for efficient influenza virus propagation. J Biol Chem. Jul 23; 279(30):30931-7.

Ehrhardt, C., Kardinal, C., Wolff, T., Wurzer, W.J., von Eichel-Streiber, C., Pleschka, S., Planz, O., und Ludwig, S. 2004. Rac1 and PAK1 are upstream of IKK-β and TBK-1 in the viral activation of interferon regulatory factor-3 (IRF-3). FEBS Lett., 567, 230-238.

Ludwig, S., Wolff, T., Ehrhardt, C., Wurzer, W.J., Reinhardt, J., Planz, O., Pleschka, S. 2004. MEK inhibition impairs influenza B virus propagation without emergence of resistant variants. FEBS Lett. Mar 12;561(1-3):37-43.

Planz, O., Pleschka, S., Oesterle, K., Berberich-Siebelt, F., Erhardt, C., Stitz, L. and Ludwig, S. 2003. Borna disease virus nucleoprotein interacts with the CDC2-cyclin B1 complex., J Virol. Oct;77(20):11186-92.

Wurzer, WJ., Planz, O., Ehrhardt, C., Giner, M., Silberzahn, T., Pleschka, S., Ludwig, S. 2003. Caspase 3 activation is essential for efficient influenza virus propagation. EMBO J. Jun 2;22(11):2717-28.

TP B13

Heimann, M., Roman Sosa, G., Martoglio, B., Thiel, H.-J. and Rümenapf, T.: Core Protein of Pestiviruses is processed at C-Terminus by Signal Peptide Peptidase, Journal of Virology, 1915-1921 (2006).

<< zurück | ^ Seitenanfang  
TP B14

Chakraborty, T., T. Hain, and E. Domann. 2000. Genome organization and the evolution of the virulence gene locus in Listeria species. Int. J. Med. Microbiol. 290:167-174

Burkle, T., T. Hain, H. Hossain, J. Dudeck, and E. Domann. 2001. Bioinformatics in medical practice: what is necessary for a hospital? Medinfo. 10:951-955.

Glaser, P., L. Frangeul, C. Buchrieser, C. Rusniok, A. Amend, F. Baquero, P. Berche, H. Bloecker, P. Brandt, T. Chakraborty, A. Charbit, F. Chetouani, E. Couve, A. de Daruvar, P. Dehoux, E. Domann, G. Dominguez-Bernal, E. Duchaud, L. Durant, O. Dussurget, K. D. Entian, H. Fsihi, F. Garcia-del Portillo, P. Garrido, L. Gautier, W. Goebel, N. Gomez-Lopez, T. Hain, J. Hauf, D. Jackson, L. M. Jones, U. Kaerst, J. Kreft, M. Kuhn, F. Kunst, G. Kurapkat, E. Madueno, A. Maitournam, J. M. Vicente, E. Ng, H. Nedjari, G. Nordsiek, S. Novella, B. de Pablos, J. C. Perez-Diaz, R. Purcell, B. Remmel, M. Rose, T. Schlueter, N. Simoes, A. Tierrez, J. A. Vazquez-Boland, H. Voss, J. Wehland, and P. Cossart. 2001. Comparative genomics of Listeria species. Science 294:849-852.

Schubert, W. D., G. Gobel, M. Diepholz, A. Darji, D. Kloer, T. Hain, T. Chakraborty, J. Wehland, E. Domann, and D. W. Heinz. 2001. Internalins from the human pathogen Listeria monocytogenes combine three distinct folds into a contiguous internalin domain. J. Mol. Biol. 312:783-794.

Carroll, S. A., T. Hain, U. Technow, A. Darji, P. Pashalidis, S. W. Joseph, and T. Chakraborty. 2003. Identification and characterization of a peptidoglycan hydrolase, MurA, of Listeria monocytogenes, a muramidase needed for cell separation. J. Bacteriol. 185:6801-6808.

Domann, E., G. Hong, C. Imirzalioglu, S. Turschner, J. Kuhle, C. Watzel, T. Hain, H. Hossain, and T. Chakraborty. 2003. Culture-independent identification of pathogenic bacteria and polymicrobial infections in the genitourinary tract of renal transplant recipients. J. Clin. Microbiol. 41:5500-5510.

Haas, S. A., M. Hild, A. P. Wright, T. Hain, D. Talibi, and M. Vingron. 2003. Genome-scale design of PCR primers and long oligomers for DNA microarrays. Nucleic Acids Res. 31:5576-5581.

Ghai, R., T. Hain, and T. Chakraborty. 2004. GenomeViz: visualizing microbial genomes. BMC. Bioinformatics. 5:198.

Wemekamp-Kamphuis, H. H., J. A. Wouters, P. P. de Leeuw, T. Hain, T. Chakraborty, and T. Abee. 2004. Identification of sigma factor Sigma(B)-controlled genes and their impact on acid stress, high hydrostatic pressure, and freeze survival in Listeria monocytogenes EGD-e. Appl. Environ. Microbiol. 70 :3457-3466.

Heidt, M. C., W. Mohamed, T. Hain, P. R. Vogt, T. Chakraborty, and E. Domann. 2005. Human infective endocarditis caused by Streptococcus suis serotype 2. J. Clin. Microbiol. 43:4898-4901.

Machata, S., T. Hain, M. Rohde, and T. Chakraborty. 2005. Simultaneous deficiency of both MurA and p60 proteins generates a rough phenotype in Listeria monocytogenes. J. Bacteriol. 187:8385-8394.

Tauch, A., O. Kaiser, T. Hain, A. Goesmann, B. Weisshaar, A. Albersmeier, T. Bekel, N. Bischoff, I. Brune, T. Chakraborty, J. Kalinowski, F. Meyer, O. Rupp, S. Schneiker, P. Viehoever, and A. Puhler. 2005. Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora. J. Bacteriol. 187:4671-4682.

Wouters, J. A., T. Hain, A. Darji, E. Hufner, H. Wemekamp-Kamphuis, T. Chakraborty, and T. Abee. 2005. Identification and characterization of Di- and tripeptide transporter DtpT of Listeria monocytogenes EGD-e. Appl. Environ. Microbiol. 71:5771-5778.

Chatterjee, S. S., H. Hossain, S. Otten, C. Kuenne, K. Kuchmina, S. Machata, E. Domann, T. Chakraborty, and T. Hain. 2006. Intracellular Gene Expression Profile of Listeria monocytogenes. Infect. Immun. 74:1323-1338.

Chatterjee, S. S., S. Otten, T. Hain, A. Lingnau, U. D. Carl, J. Wehland, E. Domann, and T. Chakraborty. 2006. Invasiveness is a variable and heterogeneous phenotype in Listeria monocytogenes serotype strains. Int. J. Med. Microbiol.

Hain, T., C. Steinweg, and T. Cakraborty. 2006. Comparative and functional genomics of Listeria spp. J. Biotechnology. (in press)

Hain T., Hossain H., Chatterjee S.S., Machata S., Volk U., Wagner S., Brors B., Haas S., Kuenne C.T., Billion A., Otten S., Pane-Farre J., Engelmann S. and Chakraborty T. 2008. Temporal transcriptomic analysis of the Listeria monocytogenes EGD-e sigmaB regulon
<< zurück | ^ Seitenanfang  
TP B15

Knobloch, J., Kunz, W. and Grevelding C.G. (2006) Herbimycin A suppresses mitotic activity and egg production of female Schistosoma mansoni. International Journal for Parasitology (in press)

Quack, T., Beckmann, S., Grevelding, C.G. (2006) Schistosomiasis and the molecular biology of the male-female interaction of S. mansoni. Berliner und Münchener Tierärztliche Wochenschrift
(in press)

Ming, Z., Dong, H., Zhong, Q., Grevelding, C.G., Jiang, M. (2006). The effect of a mutagen (N-methyl-N-nitro-N-nitrosoguanidine) on cultured cells from adult Schistosoma japonicum. Parasitology Research 98, 430-437

Grevelding, C.G. (2005) Transgenic flatworms. In: Parasitic Flatworms: Molecular Biology, Biochemistry, Immunology and Control. CABI Publishing, Wallingford, Oxon, UK. (in press)

Fitzsimmons, C.M., Schramm, G., Jones, F.M., Chalmers, I.W., Hoffmann, K.F., Grevelding, C.G., Wuhrer, M., Hokke, C.H., Haas, H., Doenhoff, M.J. and Dunne, D. (2005) Molecular characterization of omega-1; a hepatotoxic ribonuclease from Schistosoma mansoni eggs. Molecular and Biochemical Parasitology 144, 123-127

Wippersteg, V., Sajid, M., Walshe, D., Khiem, D., Salter, J.P., McKerrow, J.H., Grevelding, C.G. and Caffrey, C.R. (2005) Ballistic transformation of Schistosoma mansoni with 5´ flanking regions of two peptidase genes promotes spatially restricted expression. International Journal for Parasitology 35, 583-589

Grevelding, C.G. (2004) Schistosoma. Current Biology 14, R545

Kapp, K., Knobloch, J., Schüßler, P., Sroka, S., Lammers, R., Kunz, W. and Grevelding, C.G. (2004) The Schistosoma mansoni Src kinase TK3 is expressed in the gonads and likely involved in cytoskeletal organization. Molecular and Biochemical Parasitology 138, 171-182 (Cover photo)

Knobloch, J., Rossi, A., Osman, A., LoVerde, P. Klinkert, M.Q. and Grevelding C.G. (2004) Cytological and biochemical evidence for a gonad-preferential interplay of SmFKBP12 and SmT?R-I in Schistosoma mansoni. Molecular and Biochemical Parasitology 138, 227-236

Rossi, A., Wippersteg, V., Klinkert, M.Q. and Grevelding, C.G. (2003)
Cloning of 5´ and 3´ flanking regions of the Schistosoma mansoni calcineurin A gene and their characterization in transiently transformed parasites. Molecular and Biochemical Parasitology 130, 133-138

Grevelding, C.G. (2003) Transplantation of in vitro generated Schistosoma mansoni mother sporocysts into Biomphalaria glabrata. Parasitology Research 91, 482-485

Wippersteg, V., Ribeiro, F., Liedtke, S., Kusel, J. and Grevelding, C.G. (2003) The uptake of Texas red Bovine Serum Albumin in the excretory system of schistosomes, and it's colocalisation with ER60 promoter-induced GFP in transiently transformed adult males. International Journal for Parasitology 33, 1139-1143#

Bayne, C.J. and Grevelding, C.G. (2003) Cloning of Schistosoma mansoni sporocysts in vitro and detection of genetic heterogeneity among individuals within clones. Journal of Parasitology 89, 1056-1060

Leiers, B., Kampkötter, A., Grevelding, C.G., Link, C.D., Johnson, T.E. and Henkle-Dührsen, K. (2003) A stress-responsive glutathione S-transferase confers resistance to oxidative stress in Caenorhabditis elegans. Free Radical Biology & Medicine 34, 1405-1415

Knobloch, J., Kunz, W. and Grevelding, C.G. (2002) A reliable method to quantify DNA synthesis in multicellular organisms. Development, Growth & Differentiation 44, 559-563

Knobloch, J., Winnen, R., Quack, M., Kunz W. and Grevelding, C.G. (2002) A novel Syk-family tyrosine kinase from Schistosoma mansoni which is preferentially expressed in reproductive organs. Gene 294, 87-97

Wippersteg, V., Kapp, K., Kunz, W. and Grevelding, C.G. (2002) Characterisation of the cysteine protease ER60 in transgenic Schistosoma mansoni larvae. International Journal for Parasitology 32, 1219-1224 (Cover photo)

Wippersteg, V., Kapp, K., Kunz, W. and Grevelding, C.G. (2002) Biolistic gene transfer to generate transgenic schistosomes. Bio-Rad Technote 2768

Wippersteg, V., Kapp, K., Kunz, W., Jackstadt, P., Zahner, H. and Grevelding, C.G. (2002) HSP70-controlled GFP expression in transiently transformed schistosomes. Molecular and Biochemical Parasitology 120, 141-150 (Cover photo)

Schechtman D., Winnen R., Tarrab-Hazdai R., Ram D., Shinder, V., Kunz W., Grevelding C.G., and Arnon R. (2001). Expression and immunolocalization of the 14-3-3 protein in Schistosoma mansoni. Parasitology 123, 573-582 (Cover photo)

Kapp, K., Schüßler, P., Kunz W. and Grevelding, C.G. (2001) Identification, isolation and characterization of a Fyn-like tyrosine kinase from Schistosoma mansoni. Parasitology 122, 317-327

<< zurück | ^ Seitenanfang  

Menge, C., Stamm, I., Wuhrer, M., Geyer, R., Wieler, L. H., and Baljer G. (2001). Globotriaosylceramide (Gb3/CD77) is synthesized and surface expressed by bovine lymphocytes upon activation in vitro. Vet. Immunol. Immunop., 83, 19-36.

Liedtke, S., Geyer, H., Wuhrer, M., Geyer, R., Frank, G., Gerardy-Schahn, R., Zähringer, U., and Schachner, M. (2001). Localization and characterization of N-glycans from mouse brain N-CAM. Glycobiology, 11, 373-384.

Geyer, H., Bahr. U., Liedtke, S., Schachner, M., and Geyer, R. (2001). Core structures of polysialylated glycans present in neural cell adhesion molecule from newborn mouse brain. Eur. J. Biochem., 268, 6587-6599.

Hülsmeier, A.J., Gehrig, P.M., Geyer, R., Sack, R., Gottstein, B., Deplazes, P., and Köhler, P. (2002). A major Echinococcus multilocularis antigen is a mucin-type glycoprotein. J. Biol. Chem., 277, 5742-5748.

Kurokawa, T., Wuhrer, M., Lochnit, G. Geyer, H., Markl, J., and Geyer, R. (2002). Hemocyanin from the keyhole limpet Megathura crenulata (KLH) carries a novel type of N-glycans with Gal(?1-6)Man-motifs. Eur. J. Biochem., 269, 5459-5473.

Friedl, C.H., Lochnit, G., Dennis, R.D., Roll, C., Zähringer, U., Bahr, U., and Geyer, R. (2003). Structural elucidation of zwitterionic carbohydrates derived from glycosphingolipids of the porcine parasitic nematode Ascaris suum. Biochem. J., 369, 89-102.

Wuhrer, M., Geyer, H., von der Ohe, M., Gerardy-Schahn, R., Schachner, M., and Geyer, R. (2003). Localization of defined carbohydrate epitopes in bovine polysialylated NCAM. Biochimie, 85, 207-218.

Schmitt, S., Glebe, D., Tolle, T.K., Lochnit, G., Linder, D., Geyer, R., and Gerlich, W.H. (2004). Structure of the preS2 N- and O-linked glycans in the M surface protein in different genotypes from human hepatitis B virus. J. Gen. Virol., 85, 2045-2053.

Lochnit, G. and Geyer, R. (2004). An optimized protocol for nano-LC-MALDI-TOF-MS coupling for the analysis of proteolytic digests of glycoproteins. Biomed. Chromatogr., 18, 841-848.

Geyer, H., Geyer, R., and Pingoud, V. (2004). A novel strategy for the identification of protein-DNA contacts by photocross-linking and mass spectrometry. Nucleic Acid Res., 32, e132.

Grabitzki, J., Sauerland, V., Geyer, R., and Lochnit, G. (2005). Identification of phosphorylcholine substituted peptides by their characteristic mass spectrometric fragmentation. Eur. J. Mass Spectrom., 11, 335-344.

Yamashita, T., Wu, Y.-P., Sandhoff, R., Werth, N., Mizukami, H., Ellis, J. M., Dupree, J. L., Geyer, R., Sandhoff, K., and Proia, R. L. (2005). Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions. Proc. Natl. Acad. Sci. USA, 102, 2725-2730.

Sandhoff, R., Geyer, R., Jennemann, R., Paret, C., Kiss, E., Yamashita, T., Gorgas, K., Sijmonsma, T. P., Iwamori, M., Finaz, C., Proia, R. L., Wiegandt, H., and Gröne, H.-J. (2005). Novel class of glycosphingolipids involved in male fertility. J. Biol. Chem., 280, 27310-27318.

Pingoud, V., Geyer, H., Geyer, R., Kubareva, E., Bujnicki, J. M., and Pingoud, A. (2005). Identification of base-specific contacts in protein-DNA complexes by photocrosslinking and mass spectrometry: a case study using the restriction endonuclease SsoII. Mol. BioSyst., 1, 135-141.

Geyer, H., Wuhrer, M., Resemann, A., and Geyer, R. (2005). Identification and characterization of keyhole limpet hemocyanin (KLH) N-glycans mediating cross-reactivity with Schistosoma mansoni. J. Biol. Chem., 280, 40731-40748.

<< zurück | ^ Seitenanfang  

Hardt M and Watson AHD (1999) The distribution of input and output synapses on the central branches of cricket auditory afferent neurones: immunocytochemical evidence for GABA and glutamate in different populations of presynaptic boutons. J Comp Neurol, 403: 281-294

Hardt M and Plattner H (1999) Quantitative energy-dispersive X-ray microanalysis of calcium dynamics in cell suspensions during stimulation on a subsecond time scale: preparative and analytical aspects as exemplified with Paramecium cells. J Struct Biol, 128:187-199

Hardt M and Plattner H (2000) Sub-second quenched-flow/X-ray microanalysis shows rapid Ca2+ mobilization from cortical stores paralleled by Ca2+ influx during synchronous exocytosis in Paramecium cells. Eur. J. Cell Biol., 79: 642-652
He YB, Polity A, Österreicher I, Pfisterer D, Gregor R, Meyer BK, and Hardt M (2001)
Hall effect and surface characterization of Cu2S and CuS films deposited by RF reactive sputtering. Physica B, 308-310: 1069-1073

He YB, Polity A, Alves HR, Österreicher I, Kriegseis W, Pfisterer D, Meyer, BK, and Hardt M (2002) Structural and optical characterization of RF reactively sputtered CuInS2 thin films. Thin Solid Films, 403-404: 62-65
He YB, Kriegseis W, Bläsing J, Polity A, Krämer T, Hasselkamp D, Meyer BK, Hardt M, and Krost A (2002) Textured Cu2S thin films deposited by RF reactively sputtering. Japanese Journal of Applied Physics, 41: 1-5
He YB, Österreicher I, Polity A, Kriegseis W, Meyer, BK, and Hardt M (2002) Surface and structural characterization of CuInS2 films deposited by one-stage reactive sputtering.
International Journal of Modern Physics B, Vol. 16, Nos. 28&29, 4380-4386

He YB, Krämer T, Polity A, Hardt M, and Meyer BK (2003) Influence of the preparation conditions on the properties of CuInS2 films deposited by one-stage RF reactive sputtering.
Thin Solid Films, 431-432: 126-130

He YB, Kriegseis W, Krämer T, Polity A, Hardt M, Szyszka B, and Meyer BK (2003)
Deposition of CuInS2 thin films by reactive sputtering with a ZnO:A1 buffer layer.
Journal of Physics and Chemistry of Solids, 64: 2075-207

Husser MR, Hardt M, Blanchard M-P, Hentschel J, Klauke N, and Plattner H (2004)
One-way calcium spill-over during signal transduction in Paramecium cells: from the
cell cortex into cilia, but not in the reverse direction. Cell Calcium, 36:349-358

He YB, Krämer T, Österreicher I, Polity A, Meyer BK, and Hardt M (2005)
Post-growth treatment effects on properties of CuInS2 thin films deposited by RF reactive sputtering. Semiconductor Science and Technology, 20:685–692

Heyer J, Berger U, Hardt M, and Dunfield PF (2005) Methylohalobium crimense gen. nov. sp. nov., a moderately halophilic methanotrophic bacterium isolated from hypersaline lakes of Crimea. Int J Syst Evol Microbiol, 55:1817-26

Siefjediers A, Hardt M, Prinz M, Diener M (2006) Characterization of inositol 1,4,5-trisphosphate (IP3) receptor subtypes at rat colonic epithelium. Cell Calcium, (in press)

SFB Homepage Organisation / Kontakt Mitglieder Ausschreibungen
Forschungsprogramm Teilprojekte Publikationen Aktuelles
Workbench öffentliche Seminare interne Seminare Suche
<< zurück | ^ Seitenanfang